Endocrine Abstracts

Precedents: Thirty-nine year old Woman. Classic phenylketonuria diagnosed for neonatal screening in Germany. Good adherence to the diet from the infancy, with good metabolic control. Not response to test with BH4.Pregnancy in 2007 with good controls of phenylalanine (Phe). Son with congenital cardiopathy.Evolution: In 2013 she planed new pregnancy, departing from very good controls (<4 mg/dl) and ingestion of 22–24 Phe&#14...

Introduction: Parenteral nutrition (PN) is indicated in patients in which gastrointestinal tract is inaccessible or is severely affected. In our hospital, specialists often use commercial three-compartment bags of PN that provide standard nutritional requirements regardless a total parenteral nutrition (TPN) with macro and micronutrients adjusted to each patient by Endocrinology and Nutrition Service.Objectives: To assess the use of commercial premixed P...

Background: Full-length human prolactin (protein data bank identification P01236), the precursor of vasoinhibins, is structurally classified as a class-I helical cytokine with a four-helix bundle core and only a minimal degree of dark regions. Experimental data on the solution structure of vasoinhibins are not available.Methods: A recombinant, human vasoinhibin with a molecular mass of 16.7 kDa, comprising amino acids 29-176 of prolactin, was expressed i...

Adrenal insufficiency is a common complication of transsphenoidal surgery (TSS) for pituitary adenoma. It is very important to identify patients requiring glucocorticoid replacement, minimising risks of adrenal insufficiency.Aim: To assess the performance of early (3° day) post-TSS 08:00 a.m. cortisol measurement to detect and exclude secondary adrenal insufficiency.Methods: We selected patients undergoing TSS in our hospital ...

Introduction: Decreased bone formation has been proposed as a mechanism involved in the higher risk of fractures in diabetic patients. Some clinical studies have found that sclerostin (SCL, a negative regulator of bone formation) is increased in diabetic patients. However, there is no information about the relationship between SCL and new onset diabetes after transplantation (NODAT). The aim of our study is to evaluate serum SCL levels in a cohort of patients with liver transp...

With preterm regression of the hyaloid vascular system, the human vitreous becomes devoid of blood vessels and maintains an avascular, transparent state throughout life. However, diseases of the developing and mature retina, such as retinopathy of prematurity or proliferative diabetic retinopathy (PDR), often result in the invasion of blood vessels into the vitreous, with a risk of causing vitreous hemorrhage, retinal detachment and, consequently, loss of vision or blindness. ...

Introduction: Growth hormone deficiency (GHD) is associated with worsening body composition and growth hormone replacement therapy (GHRT) has shown to improve it in several studies. The objectives of this study were to evaluate the effects of long-term GHRT on body composition in adult patients with GHD andassess, in this population, the agreement between two different methods to measure fat mass that are total body fat mass (FM) and relative fat mass (RFM).<p class="abste...

Objective: To investigate factors associated with the presence and growth rate of thyroid nodules(TN) in patients with acromegaly.Methods: We retrospectively evaluated the medical records of 52 patients with acromegaly followed in our institution (University Hospital Ramón y Cajal). The frequencies of TN and papillary thyroid cancer (PTC) and potential factors associated with nodular thyroid disease (NTD) were investigated. In patients with NTD (<em...

Introduction: Protocols for identifing and managing hyperglycemia and diabetes in hospital are necessary. Glycemic goals in non critical inpatients are:140 mg/ml(preprandial) and 180(posprandial),oral antidiabetic drug(OADs) withdrawn, avoid hypoglycemias, basal/bolus insulin (nor sliding scale) and request glycosylated haemoglobin.Aims: To evaluate the implementation of a protocol for management of diabetes(PHD) during the years 2009 and 2010 in our Hos...

Introduction: Simultaneous pancreas kidney transplant (SPK) is a prime line treatment option in patients with type 1 diabetes and chronic kidney failure. The glucose control during perioperatory period can be a prognostic factor for transplant. Actually, the utility of the continuous glucose monitoring is not well defined. Our objective was to study the utility of a continuous glucose monitoring system during the simultaneous pancreas kidney transplant.M...